@rabbithearth @thegibson open sourcing HRT may be fairly difficult but making the HRT currently in circulation go much, much further may be within reach https://stickies.neocities.org/stickies.html

« Many people have trouble getting hormones, whether because of cost, lack of local services, uncooperative or downright hostile medical professionals, and it completely sucks. People have talked about finding ways to synthesize hormones at home, and that is originally what I was planning to work on. But the more I thought about it, the more I became worried that it wasn't something just anyone was going to be able to do. Even if I could synthesize estradiol at home I would still want to purify and measure it, and all that would take a bunch of specialized equipment. Pain in the ass.

At some point I had the thought that estradiol is easy and cheap to make industrially, and that there is a lot of it out in the world already as tablets, so maybe I could take advantage of that by finding a better way to use what is already there. I started thinking about making a controlled release formulation. I figured even if I didn’t do as well as patches and ended up with a daily dose of 0.5 mg, it would still be only 1/8th of my prescribed daily dose of 4 mg! That would mean I would have enough estrogen in my possession for 8 times as many doses, and much more stable blood estradiol levels. It was interesting enough to be worth trying. »

(link describes a process for estradiol; similar methodology may be applicable to other HRT formulations though)

[do not take medical advice off the internet]